The Ministry of Foreign Affairs of Ukraine is the Ukrainian government ministry which oversees the foreign relations of Ukraine.

Originally the Ministry was established as the General Secretariat of Nationalities as part of the General Secretariat of Ukraine and was headed by the federalist Serhiy Yefremov. Due to the Soviet intervention the office was reformed into a ministry on December 22, 1917. About the same time another government was formed, the Soviet, that proclaimed the Ukrainian government to be counter-revolutionary. The Ukrainian Soviet government also reorganized its office on March 1, 1918. In 1923 the office was liquidated by the government of Soviet Union and reinstated in 1944, twenty years later. The first Soviet representatives were not much of a notice until the appointment of the Bulgarian native Christian Rakovsky in 1919.